Press Research sCD14

New research links IC14 target to dementia

New research published in the world’s leading journal Neurology reports a link between higher levels of an inflammatory marker called sCD14 and a higher risk of developing dementia. 

The study looked at blood samples and dementia diagnosis of more than 4,700 people over a decade. Researchers found that people with higher blood levels of sCD14 also had a higher risk of dementia.

Each standard deviation unit increase in sCD14 corresponded with a 12% risk increase in dementia, brain ageing and decline in executive function.

Lead researcher Dr Matthew Pase said that tremendous progress was being made in the development of blood biomarkers in dementia and that further investigation could help to understand the clinical impact of this discovery. 

“The ultimate goal here is to improve early detection in dementia so that changes can be made ahead of developing the disease.” 

Dr Matthew Pase

Implicit Bioscience’s biologic immunotherapy IC14 blocks sCD14 in patients and is currently being developed for the treatment of ALS/MND.

For more about this research, read the Neurology Abstract here:


On June 3, 2020, the US Food and Drug Administration approved the company’s Investigative New Drug Application (IND) to permit the commencement of a 300 patient, clinical study of IC14 together with remdesivir in COVID-19 patients at risk of acute respiratory distress syndrome (ARDS). The company expects to be able to make further announcements about the structure and sponsorship of this breakthrough clinical study during July, 2020. See the listing at for further details